Project partner: UCL
The NMR Research Unit based at the UCL Institute of Neurology has a strong tradition of methodological development for quantitative Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) methods in the central nervous system (CNS).
The Physic team is particularly focused on developing, implementing and translating methods for studying a number of pathophysiological processes occurring in multiple sclerosis (MS), using standard and advanced imaging techniques applied to brain and spinal cord, as well as optic nerve wherever possible.
Methods include:
- Microstructural imaging using models of water diffusion in tissue;
- Myelin imaging, exploiting the magnetisation transfer phenomenon;
- Tissue loss, through brain atrophy from high resolution imaging;
- Sodium imaging and spectroscopy;
- Functional imaging, both task dep
Project contribution
The UCL team will contribute analysis methods for quantitative T1 and T2 mapping as well as for diffusion imaging.
Contact
Prof. Claudia Wheeler-Kingshott
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Prof Daniel Alexander
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